EXPERIMENTAL HYPERCHOLESTEROLEMIA
نویسندگان
چکیده
منابع مشابه
Growing Rats Are Resistant to Bone Loss Associated With Short-Term Hypercholesterolemia: A Preliminary Experimental Study
We aimed to evaluate the potential of growing rats as a model of osteoporosis induced by short term hypercholesterolemia. Twelve growing female Sprague-Dawley rats were randomly allocated into two groups. Control rats received standard diet while rats in group 2 were fed with diet contained 20% sunflower oil, 2% cholesterol and 0.5% cholic acid for 2 weeks and then a diet contained 10% sunflowe...
متن کاملIn vivo renal vascular and tubular function in experimental hypercholesterolemia.
Hypercholesterolemia (HC) is often associated with impaired peripheral and coronary vascular responses to endothelium-dependent vasodilators, which are probably due to low bioavailability of nitric oxide. To examine the effect of HC on renal vascular and tubular function, 22 domestic pigs were studied after being fed a 12-week normal (n=11) or HC (n=11) diet. Renal regional perfusion and intrat...
متن کاملDifferential effect of experimental hypertension and hypercholesterolemia on adventitial remodeling.
OBJECTIVE Intima-media remodeling, as frequently assessed by changes in the external elastic lamina-to-lumen area (EELLA), is well-described in coronary artery disease in contrast to adventitial remodeling, especially in the early disease stage. METHOD AND RESULTS Female domestic pigs were randomized to one of the following 12-week treatment groups: normal diet (N; n=6), high-cholesterol diet...
متن کاملEnhanced coronary vasa vasorum neovascularization in experimental hypercholesterolemia.
Coronary arteries contain a network of vasa vasorum in the adventitia. The three-dimensional anatomy of the vasa vasorum in early coronary atherosclerosis is unknown. This study was designed to visualize and quantitate the three-dimensional spatial pattern of vasa vasorum in normal and experimental hypercholesterolemic porcine coronary arteries, using a novel computed tomography technique. Anim...
متن کاملAltered myocardial microvascular 3D architecture in experimental hypercholesterolemia.
BACKGROUND Experimental hypercholesterolemia (HC) impairs intramyocardial microvascular function. However, whether this is associated with alterations in microvascular architecture remained unknown. Using a novel 3D micro-CT scanner, we tested the hypothesis that HC is associated with an alteration in the microvascular architecture. METHODS AND RESULTS Pigs were euthanized after 12 weeks of e...
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ژورنال
عنوان ژورنال: Archives of Internal Medicine
سال: 1916
ISSN: 0003-9926
DOI: 10.1001/archinte.1916.00080120048002